Protein Family Classification
Discovery of New Knowledge by
Using Information Embedded within
Families of Homologous Sequences and Their Structures
Superfamily, Domain, and Motif Classification
Superfamily Concept
l End-to-End Similarity & Same Overall Domain Architecture
Significance
l Improve Sensitivity of Protein Identification
l Provide Complete Clustering for Database Organization
l Detect and Correct Genome Annotation Errors Systematically
l Drive Other Annotations
l Stimulate Evolution, Genomics and Proteomics Research