7
Genome Era Challenges:
Transitive Catastrophe
* Error Propagation: At least 17 Sequences Incorrectly Named as IMP Dehydrogenase or Related (Propagated to KEGG & WIT)
A rational protein family classification, based on both
global and local similarity, can prevent or correct many of such errors.
A
C
B
A -> B -> C  =>  A -> C