Protein Family Classification for Functional Genomics

Protein Family Classification

Superfamily, Domain, and Motif Classification

Superfamily Concept

lEnd-to-End Similarity & Same Overall Domain Architecture

Significance

lImprove Sensitivity of Protein Identification

lProvide Complete Clustering for Database Organization

lDetect and Correct Genome Annotation Errors Systematically

lDrive Other Annotations

lStimulate Evolution, Genomics and Proteomics Research

Discovery of New Knowledge by

Using Information Embedded within

Families of Homologous Sequences and Their Structures